Sepsis is one of the most frequent causes of death worldwide, but there are challenges in collecting reliable data at the population level
From data published in 2020, there were 48.9 million cases and 11 million sepsis-related deaths worldwide, representing 20% of all global deaths.
Almost half (20 million) of all estimated sepsis cases worldwide occurred in children under 5 years of age.
For every 1000 hospitalized patients, an estimated 15 patients will develop sepsis as a complication of receiving health care.
While sepsis can affect any individual worldwide, significant regional disparities in incidence and mortality exist with the highest rates in lower-middle-income countries (LMICs).
Sepsis is costly; the average hospital-wide cost of sepsis was estimated to be more than US$ 32 000 per patient in high-income countries.